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Nonbacterial prostatitis (NBP), also known as chronic pelvic pain syndrome (CPPS), is the most common and least understood form of prostatitis. It is a condition in which the patient exhibits many of the symptoms of prostatitis without any demonstrable infection.

Causes
Unfortunately, little is known about what causes NBP. It is believed to occur eight times more often than bacterial prostatitis.

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What are the signs and symptoms of the condition?
The symptoms of NBP typically resemble those of chronic bacterial prostatitis: rapid onset, chills, fever, pain in the lower back and genital area, body aches, burning or painful urination, increased urinary frequency and urgency, often at night, and occasionally visible blood in the urine. In cases of NBP, however, urinary tract infections are rare.

Symptoms come and go, disappearing and reappearing without warning or apparent reason. The patient will experience good and bad spells. This can be frustrating and debilitating, as the patient typically will seek treatment on the basis of symptoms he and his physician assume are associated with bacterial prostatitis. Medications prescribed for bacterial prostatitis may appear to work when the condition wanes, misleading them to think the problem has been cured. This can give rise to great anxiety when symptoms return, and in fact many men report a worsening of their symptoms during times of stress.

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How is this condition diagnosed?
A diagnosis of NBP usually is made after repeated unsuccessful attempts to treat what is presumed to be bacterial prostatitis. Although microscopic examination of prostate massage specimens may show increased numbers of white blood cells, ultimately, no definite source of infection can be identified. Urine and prostatic fluid routinely fail to show the presence of any infecting organisms. Often the diagnosis is made only after various unsuccessful drug treatments, numerous doctor's visits and considerable expense.

Occasionally, doctors will diagnose patients whose NBP develops from a lack of sexual activity. This so-called "congestive prostatitis" is thought to be the result of a lack of ejaculation. when semen stays too long in the prostate and causes inflammation.

A converse diagnosis of "exhaustive prostatitis" or "overuse prostatitis" may be made in men whose NBP symptoms appear to be caused by excessive ejaculation. In both cases, a sexual history is essential to accurate diagnosis, and modification of sexual activity usually is prescribed.

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What are the treatments?
There is no known cure for NBP. Because antibiotics generally are ineffective at combating it, treatment often devolves on lessening the patient's symptoms with a variety of pain-relief medications and "home remedies." These include:
  • Hot baths ("sitz baths")-A helpful temporary treatment for all forms of prostatitis, warm water and relaxation can soothe the prostate and relieve symptoms.
  • Drinking plenty of water-This dilutes the acidity and salt in urine and from such food irritants as caffeine, cranberry or citrus acid, colas, spices, alcohol, etc..
  • Stress management techniques-These may help patients who note their symptoms worsening during periods of anxiety or stress.
  • "Alpha blockers"-These drugs relax the bladder's sphincter muscles, and may provide relief to patients who experience difficulty urinating.
  • "Parasympathetic blockers-These drugs relax the muscles that surround the bladder, making them less sensitive, and may provide relief to patients who have urgency and frequency of urination.
  • Nonsteroidal anti-inflammatory medications - Over-the-counter medicines like ibuprofen and naproxen, as well as stronger anti-inflammatory drugs, may provide some symptom relief.
  • Transurethral Microwave Therapy (TUMT)-Heating the prostate with a microwave probe inserted through the penis or rectum has provided symptom relief in some experimental situations.

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